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[ I've only seen a demo ]
SimPatch simulates a whole-cell patch recording setup, including a realistic looking interface and the ability to do a wide variety of experiments. There is a nice review of this program on the CTI site so I'll refer you there for more details. I think this is the nicest of the current crop of neurobiology teaching programs.
Note that this is one of a whole series of programs from this group, including a muscle simulation, a heart simulation, and a couple others. I haven't seen any of the others and the web page is in german, but the pictures look quite good.
Computer: Windows and Macintosh
Source: Georg Thieme Verlag International, Stuttgart, Germany. email clarisse.vauchelle@thieme.de or hschneid@mailer.uni-marburg.de
Cost: High